Never say never when it comes to fantasy football lineup decisions -- every roster-worthy player can be started in the right situation. However, when facing tough decisions you should err on the side of caution with the following players this week.
Terrelle Pryor, QB, Oakland Raiders at Kansas City Chiefs
The young passer put on a clinic against the Chargers in Week 5 play, logging 22 standard fantasy points on the night, and completing 78.3 percent of his attempts. Life won't be so easy against the Chiefs this Sunday. KC has limited quarterbacks to 224.0 passing yards and less than a touchdown per game, resulting in an average of 15.4 fantasy points against.
Eddie Lacy, RB, Green Bay Packers at Baltimore Ravens
The Packers' coaching staff knows the best way to beat the Ravens is through the air, and Lacy's fantasy production will suffer as a result. Baltimore has yielded the fewest points (10.2) to running backs per game, stemming from averages of 82.0 rushing yards and 26.0 receiving yards, while allowing just one touchdown to the position in 2013.
Frank Gore, RB, San Francisco 49ers vs. Arizona Cardinals
Look, I am not saying to bench Gore in most situations. However, this one could be a prime opportunity to take that chance if you have a tantalizing bench option. He has not topped 100 yards of total offense in his last four meetings with the Cards, and the veteran rusher has just two touchdowns in his last five games against Arizona. Consider Gore a fringe play in Week 6.
Larry Fitzgerald, WR, Arizona Cardinals at San Francisco 49ers
The 49ers should shade coverage his way all game long, which will force the cautious Carson Palmer to look elsewhere to unload the ball. Fitz was awful in two starts against San Fran in 2012, too, totaling a 7-65-0 line. Only the Houston Texans have been stronger against wideouts this year than the 'Niners. Consider him a high-risk, low-reward option this week.
DeSean Jackson, WR, Philadelphia Eagles at Tampa Bay Buccaneers
D-Jax says Bucs corner Darrelle Revis cannot keep up with him, and while he may be right, the Buccaneers' safeties are more than capable of supplying help over the top. Jackson also has to deal with Nick Foles likely replacing Michael Vick (hamstring) under center this week, which further muddies the situation. Jackson is a desperation play for Week 6.
Nate Washington, WR, Tennessee Titans at Seattle Seahawks
Regardless of whether it is cornerback Richard Sherman or defensive counterpart Brandon Browner, Washington faces a daunting task. A favorite of quarterback Jake Locker (hip), the veteran wideout doesn't seem to have the necessary chemistry with interim starting passer Ryan Fitzgerald to overcome a matchup of this caliber. Washington should be left for your bench, unless you play in a very deep league.
Kyle Rudolph, TE, Minnesota Vikings vs. Carolina Panthers
Following a breakthrough 2012 season, Rudolph has been a colossal disappointment for fantasy owners. I realize I am not going out on a limb here, but don't expect his fortunes to improve this week. He has just 12 receptions in four games and has averaged a pathetic 8.6 yards per reception. As if that was bad enough, the Vikes play a Panthers team that has surrendered only 3.8 non-PPR points per outing to his position.
Dan Bailey, PK, Dallas Cowboys vs. Washington Redskins
Bailey has been productive for fantasy purposes this year, but if you like to play the matchups, he can be cast to the wire in favor of a better option this week. Washington doesn't give up much in the way of field goal attempts -- only six in four games this year -- and instead allows enemy kickers to knock through extra points in droves.
Cleveland Browns DST vs. Detroit Lions
The caveat: Does Calvin Johnson (knee) play? Stick it out until gameday inactives are released Sunday morning. Here's the deal ... Megatron opens up so much for Detroit's offense, opposing D's cannot focus on stopping any one area without playing with fire. The Lions have done a great job of protecting Matthew Stafford. Detroit allowed just eight sacks and turned over the ball seven times in five games.