Never say never when it comes to fantasy football lineup decisions -- every roster-worthy player can be started in the right situation. However, when facing tough decisions you should err on the side of caution with the following players this week.
Eli Manning, QB, New York Giants at Kansas City Chiefs
It probably will be mocked that isn't a stretch to tell you that Eli isn't a good play this week after his debacle last Sunday. How much worse can he get, right? Point taken. However, he is unlikely to get much better this week. KC has been stout against the position and hosts the Giants in hostile environment. Justin Houston, meet Eli. Eli, meet turf. There are better QB plays off the wire than Manning.
Reggie Bush, RB, Detroit Lions vs. Chicago Bears
The numbers suggest Bush should be in for a long day, especially in PPR leagues. Chicago checks in as the strongest D against RBs through three weeks. Trusting him on turf after an injury makes me nervous. I won't say to outright bench the electrifying rusher, rather lower your expectations. He's a lot closer to being a flex play than a low-end RB1 this week.
Rashard Mendenhall, RB, Arizona Cardinals at Tampa Bay Buccaneers
Mendenhall is another player most owners do not need to be told to bench, but injuries and bye teams may force your hand. Wide receiver Larry Fitzgerald (hamstring) is banged up, which doesn't bode well for a strong aerial game to take pressure off Mendy. A pair of awesome safeties allows Tampa Bay eliminate the vertical attack and concentrate on everything underneath.
Greg Jennings, WR, Minnesota Vikings vs. Pittsburgh Steelers
There is not much redeeming about Jennings versus Ike Taylor or the Steelers' secondary, in general. Minnesota also has question marks at quarterback, and that isn't even a joke about Christian Ponder's ineffectiveness. Jennings belongs on all benches until he has a cupcake matchup or proves otherwise versus a formidable opponent, not to mention facing the toughest wide receiver D in the league through three weeks.
Larry Fitzgerald, WR, Arizona Cardinals at Tampa Bay Buccaneers
Bucs head coach Greg Schiano says cornerback Darrelle Revis won't drape Larry Fitzgerald all day, but that's hard to count on. Fitz is coming off a hamstring strain and could be sidelined at any time because of it. Tampa Bay boasts the third best defense of receivers after three matchups.
Santonio Holmes, WR, New York Jets at Tennessee Titans
Holmes is coming off a monster game but could struggle to be worth playing in Week 4. He appears to be getting his football legs back but runs into a tough matchup against a Titans' D that has allowed just two TDs to wideouts on this young season. You can be sure Tennessee's coaching staff took notice of Holmes' strong Week 3 performance.
Brandon Myers, TE, New York Giants at Kansas City Chiefs
New York's offense is in shambles right now, and KC has been impressive against the position, particularly the past two weeks. By impressive, I mean they have been the second best team versus tight ends on the year. Myers should be involved but may not be able to go very far with the way the Chiefs have been swarming to the ball.
Matt Bryant, PK, Atlanta Falcons vs. New England Patriots
Picking a place kicker is often tricky, but the numbers are not in Bryant's favor. He faces a Patriots team that has given up only three total field goal attempts and four touchdown toppers on this immature season.
New York Jets, DST at Tennessee Titans
Would you believe the Titans are one of two teams without a turnover on the year? New York has been OK on D this season, but the way Tennessee has protected the ball makes the Jets a suspect fantasy start. Look elsewhere for your matchup play.